Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies

Launched by CHILDREN HOSPITAL AND INSTITUTE OF CHILD HEALTH, LAHORE · Mar 25, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of two treatments for scabies in children aged 6 to 15 years. Scabies is a skin condition caused by tiny mites that can cause severe itching and irritation. The trial aims to compare the outcomes of using permethrin, which is a cream applied to the skin, and ivermectin, which is a pill taken by mouth. The researchers will divide 90 children into three groups: one group will receive a single application of permethrin, another group will receive two applications of permethrin, and the third group will take a single dose of ivermectin. The children will be checked for improvement in their skin condition two weeks and four weeks after treatment.

To participate in this trial, children must be between 6 and 15 years old and have been diagnosed with scabies. However, children with a history of frequent scabies, allergies to the treatments, or certain skin or health conditions will not be eligible. Throughout the study, researchers will carefully record how well each treatment works, focusing on the number of skin lesions and the level of itching. This information will help determine the best option for treating scabies in children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 6-15
• • Both genders
• • Diagnosed with scabies (as per operational definition)
• Exclusion Criteria:
• • Children with recurrent scabies on medical record
• • Known allergy to ivermectin or permethrin.
• • Widespread eczema or impetigo.
• • Liver dysfunction or renal failure