Barrett's Esophagus in Patients with GERD

Launched by ASSIUT UNIVERSITY · Mar 25, 2025

Keywords

ClinConnect Summary

Barrett's esophagus (BE) is a metaplastic change of the lining of the esophagus with replacement of the normal squamous epithelium with columnar epithelium containing goblet cells. It is the most severe histological consequence of chronic gastroesophageal reflux and predisposes to the development of adenocarcinoma of the esophagus (Spechler SJ et al., 2001).

BE develops when metaplastic columnar mucosa replaces the normal esophageal squamous epithelium of the esophagus in response to damage caused by gastroesophageal reflux . The columnar-lined esophagus contains a mosaic of 3 different ce...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults diagnosed with GERD based on clinical symptoms and/or 24-hour pH monitoring or esophageal manometry.
• • Patients willing to undergo endoscopic examination
• • Exclusion criteria: Patients with a history of esophageal cancer.
• • Patients with other esophageal diseases, such as eosinophilic esophagitis, infections, or motility disorders.
• • Patients who are unable to consent or participate in the study