Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Mar 26, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to quickly assess chest pain in patients coming to the Emergency Department (ED) who may be experiencing Acute Coronary Syndrome (ACS). Researchers want to see if using a quick blood test called high-sensitivity troponin (hs-cTn) can provide faster results and help doctors make better decisions about patient care. The hope is that this test will reduce the amount of time patients spend in the ED and improve overall care, while also benefiting the hospital financially.

To participate in this study, patients need to be at least 18 years old and have symptoms that suggest they might be having a heart issue, like chest pain, shortness of breath, or other similar discomfort. Participants will receive standard care, which includes having their heart activity monitored through an ECG and having a blood sample taken. However, those with certain serious conditions, such as very unstable vital signs or those already being treated for a heart attack, will not be eligible. If you or a loved one is experiencing chest pain and meets the criteria, this trial could play an important role in improving care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age greater than or equal to18 years
• * Symptoms suggestive of acute coronary syndrome:
• • Acute chest, epigastric, neck, jaw or arm pain or discomfort or pressure without apparent non-cardiac source
• • Shortness of breath, nausea, vomiting, fatigue/malaise, or
• • Other equivalent discomfort suggestive of an myocardial infarction (MI)
• • Electrocardiogram (ECG) ordered as part of standard of care
• • At least one troponin collected as standard of care
• • Study specific blood sample collected within ± 5 minutes of clinical draw
• Exclusion Criteria:
• • ST-segment elevation myocardial infarction (STEMI) Activation
• • Unstable vitals signs: symptomatic hypotension at the time of enrollment (systolic \< 90 mm Hg), tachycardia (HR\>120), bradycardia (HR\<40), and hypoxemia (\<90% pulse-oximetry on room air or normal home oxygen flow rate)
• • Central laboratory hs-cTn testing resulted or in process (\>5 minutes) prior to study accrual
• • Prior enrollment
• • Terminal diagnosis with life expectancy less than 6 months