The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery
Launched by BOSTON CHILDREN'S HOSPITAL · Mar 26, 2025
Trial Information
Current as of April 29, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the connection between certain proteins in the blood, called Tau and GFAP, and brain injury in children under 18 years old who are having heart surgery. These surgeries often use a heart-lung machine, which can affect the brain, and the researchers want to understand how these proteins might help indicate if brain injury occurs during or after the surgery.
To participate, children must be under 18 and scheduled for heart surgery at Boston Children's Hospital that involves the use of a heart-lung machine. However, kids who are in very poor health, require emergency surgery without enough time for consent, or have certain medical conditions, like blood disorders or cancers, will not be eligible. If your child qualifies, they will provide blood samples before and after the surgery to help the researchers learn more about the potential impacts on brain health. This study is important because it could lead to better ways to protect the brain during heart surgery in young patients.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • less than 18 years old
- • undergoing cardiac surgery with cardiopulmonary bypass at Boston Children's Hospital
- Exclusion Criteria:
- • undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent
- • patient in a moribund condition American Society of Anesthesiology (ASA 5)
- • patient with a hematological and/or oncological disease
- • Jehovah witnesses
- • patient on preoperative mechanical ventilation
About Boston Children's Hospital
Boston Children's Hospital is a leading pediatric healthcare institution renowned for its commitment to advancing child health through innovative research and exceptional clinical care. As a prominent clinical trial sponsor, the hospital leverages its extensive expertise in pediatric medicine to conduct rigorous and ethically sound research studies aimed at improving treatment options and outcomes for children. With a collaborative approach that integrates cutting-edge technology and multidisciplinary teams, Boston Children's Hospital is dedicated to translating scientific discoveries into practical applications that enhance the well-being of young patients and their families.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported