Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery

Launched by RENJI HOSPITAL · Mar 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called esketamine on two common issues that can occur after major surgery in older patients: postoperative delirium (POD) and sleep disturbances. POD is a state of confusion that can happen after surgery, and it can lead to longer recovery times and increased hospital stays. Sleep problems can contribute to POD and are also a symptom of it. The researchers believe that esketamine may help reduce inflammation, which could improve sleep and potentially lower the risk of developing POD.

To be eligible for this trial, participants must be at least 65 years old and scheduled for a major surgery that is not heart-related. They should also be in reasonably good health, as indicated by specific medical criteria. Participants will need to voluntarily agree to take part and will be asked to complete some questionnaires and tests. The trial is not yet recruiting participants, but if you or someone you know might fit the criteria, this could be an opportunity to help advance our understanding of how to better support older adults during recovery from surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≧ 65 years;
• • 2. ASA Ⅰ-Ⅲ;
• • 3. Elective major non-cardiac surgery;
• • 4. Voluntary signed informed consent.
• Exclusion Criteria:
• • 1. People with mental illness;
• • 2. Suffering from serious central nervous system disorders such as arkinson's disease, Alzheimer's disease, etc;
• • 3. Elevated intracranial pressure;
• • 4. Emergency or trauma surgery;
• • 5. Prior history of postoperative delirium or postoperative cognitive decline;
• • 6. The patient has impaired hearing or impaired vision;
• • 7. Suffering from severe systemic underlying diseases (e.g. cardiac insufficiency, malignant arrhythmia, malignant hypertension, hepatic failure, renal failure, etc.);
• • 8. The patient is in chronic pain;
• • 9. The patient is severely malnourished;
• • 10. Patients with stage 3 or 4 malignant tumors, pancreatic cancer, allbladder cancer, cholangiocarcinoma and other tumors with high malignancy and poor prognosis.
• • 11. history of allergy to or contraindication to esketamine;
• • 12. inability or unwillingness to complete questionnaires or clinical testing;
• • 13. Unable or unwilling to use a postoperative intravenous analgesic pump.