Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery

Launched by RENJI HOSPITAL · Mar 23, 2025

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≧ 65 years;
• • 2. ASA Ⅰ-Ⅲ;
• • 3. Elective major non-cardiac surgery;
• • 4. Voluntary signed informed consent.
• Exclusion Criteria:
• • 1. People with mental illness;
• • 2. Suffering from serious central nervous system disorders such as arkinson's disease, Alzheimer's disease, etc;
• • 3. Elevated intracranial pressure;
• • 4. Emergency or trauma surgery;
• • 5. Prior history of postoperative delirium or postoperative cognitive decline;
• • 6. The patient has impaired hearing or impaired vision;
• • 7. Suffering from severe systemic underlying diseases (e.g. cardiac insufficiency, malignant arrhythmia, malignant hypertension, hepatic failure, renal failure, etc.);
• • 8. The patient is in chronic pain;
• • 9. The patient is severely malnourished;
• • 10. Patients with stage 3 or 4 malignant tumors, pancreatic cancer, allbladder cancer, cholangiocarcinoma and other tumors with high malignancy and poor prognosis.
• • 11. history of allergy to or contraindication to esketamine;
• • 12. inability or unwillingness to complete questionnaires or clinical testing;
• • 13. Unable or unwilling to use a postoperative intravenous analgesic pump.