Exploring Glycemic Responses Through Continuous Monitoring in a Healthy Population

Launched by ZOE GLOBAL LIMITED · Mar 21, 2025

Keywords

ClinConnect Summary

The PREDICT REFINE trial is a research study aimed at understanding how our diets affect blood sugar levels in healthy people. Participants will wear a Continuous Glucose Monitor (CGM) for two weeks to track their blood sugar levels. They will also be asked to eat a standard meal before and after following a personalized dietary plan. By doing this, researchers hope to learn how well the CGM works, how our diet influences blood sugar over time, and how our gut health might play a role in managing blood sugar levels.

To take part in this study, you need to be at least 18 years old and have a BMI (Body Mass Index) of 18.5 or higher. You must be living in the UK and able to follow the study instructions. Some health conditions may prevent you from participating, such as certain allergies, recent surgeries, or serious medical issues like heart attacks or diabetes that requires medication. If you qualify and decide to join, you can expect to wear the CGM, provide a stool sample, and share details about your diet and health during the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Enrolled in the ZOE product \& purchased a Gut Health Retest at month 4
• • Any sex
• • Minimum 18 years of age
• • Body mass index (BMI) greater than or equal to 18.5 kg/m2
• • If under care for any chronic medical conditions (including type 2 diabetes), you have confirmed with your treating physician that this sub study is safe for you. This does not apply to conditions listed in the exclusion criteria.
• • Able and willing to comply with the study protocol and provide informed consent before your ZOE Gut Health Retest is fulfilled and posted.
• • Live in the United Kingdom
• Exclusion Criteria:
• • Cannot safely eat the standardised meals (part of the ZOE product) which contain standard UK ingredients, e.g. due to allergy or recent gastrointestinal surgery
• • Cannot safely use the cgm (per manufacturer's contraindications for use including critically ill, pregnant, receiving dialysis, or have an implantable medical device)
• • Are pregnant
• • Have had a heart attack (myocardial infarction), stroke/transient ischemic attack (TIA), or major surgery in the last two months
• • Are unable to read and write in English, as the ZOE app is only available in English.
• • Are diagnosed with type 1 diabetes and/or require the use of exogenous insulin or oral hypoglycaemic medications to regulate blood sugar levels
• • Have an active eating disorder (e.g. anorexia nervosa or bulimia nervosa)
• • Have an active gut or digestive system disease (e.g. IBD, Crohn's disease or ulcerative colitis)
• • Are undergoing chemotherapy treatment for cancer
• • Unable to complete study tasks by 31 May 2025