The Effect of Propolis Administration on Cholesterol Level in Diabetic Type 2 Patients

Launched by INDONESIA UNIVERSITY · Mar 28, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring whether propolis, a natural substance made by bees, can help change cholesterol levels in people with type 2 diabetes. Specifically, the researchers want to see if taking propolis can lower bad cholesterol (LDL) and raise good cholesterol (HDL) over an 8-week period. Participants will take either propolis or a placebo (a similar-looking liquid that has no active ingredients) twice a day, based on their weight, while visiting a local health center every two weeks for check-ups and blood tests.

To be eligible for this study, participants should have controlled type 2 diabetes (with an HbA1c level below 7.5%), a body mass index (BMI) between 23 and 35, and be on cholesterol-lowering medication. However, individuals who use insulin, have allergies to bee products, smoke, drink alcohol, have liver or kidney issues, are pregnant or breastfeeding, or have a history of heart disease will not be able to join. This trial is currently recruiting participants of all genders aged between 18 and 65 years.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Controlled Diabetes Mellitus type 2 with HbA1c \<7.5%
• • BMI 23-35 kg/m2
• • On anti-cholesterol therapy
• Exclusion Criteria:
• • Using injection therapy (insulin or GLP-1 RA)
• • History of bees product allergy
• • Active smoker
• • Consuming alcohol
• • Altered liver (ALT\>35 IU/L) and kidney (eGFR\<90 mL/min) function
• • Pregnant and breastfeeding women
• • History of cardiovascular disease (heart attack, stroke)