Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Mar 25, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating a new way to treat soft tissue sarcoma (a type of cancer) in the arms and legs by using a method called hypofractionated radiotherapy. This treatment aims to shrink the cancer while also protecting the healthy tissue around it, making it easier to perform surgery later on. The trial is currently looking for participants who are 18 years or older and have been diagnosed with soft tissue sarcoma in their limbs or trunk. To join, participants need to be able to give their consent, have a specific type of cancer that is eligible for surgery, and may face challenges with the standard treatment that usually requires daily visits for five weeks.

If you or someone you know is interested in participating, you can expect to receive focused radiation treatment over a shorter period of time, which may be more manageable for those with concerns about travel or time away from work. It's important to note that this trial is not for everyone; for example, individuals with cancer that has spread to other parts of the body or those who have had previous radiation in the treatment area cannot participate. Overall, this study aims to find a more convenient and effective way to treat soft tissue sarcoma while keeping patients' quality of life in mind.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Willingness and provision of informed consent via signed and dated copy.
• • Histologically confirmed STS of extremity or trunk.
• • Male or female, aged greater than or equal to 18 years old
• • ECOG performance status 0-3
• • Meets screening criteria for receipt of radiotherapy.
• • Deemed eligible for wide local excision.
• • Patient and/or physician identified possible barriers to receiving a 5-week course of conventionally fractionated preoperative radiotherapy. Potential barriers include but are not limited to concern for local progression that could precluded or complicate limb sparing surgery, concern for distant progression that could result in patient being non-operative, financial and/or physical burden of travel for daily treatments, financial burden of time away from work or caregiving.
• Exclusion Criteria:
• • Distant metastatic disease
• • Prior radiation therapy in the proposed treatment area
• • Simultaneous treatment of another malignancy
• • Women who are pregnant or plan to become pregnant during the period of radiation therapy
• • Planned concurrent administration of chemotherapy and radiation therapy