A Pilot Study of Synbiotics in Adults With Depressive Symptoms

Launched by GENIEBIOME LIMITED · Mar 25, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a special combination of probiotics and prebiotics, known as a synbiotic formula (called MQU10), can help improve mood and overall well-being in adults experiencing mild to moderate symptoms of depression. The study aims to see if this formula can make a positive difference for those who may be feeling down but do not have severe depression.

To participate, individuals need to be at least 18 years old and have a specific score on a depression questionnaire that indicates mild to moderate symptoms. However, some people won't be eligible, such as those with a history of serious mental health issues or certain medical conditions. Participants will complete self-report questionnaires and will need to understand and sign a consent form before joining. This study is not yet recruiting, but it represents an exciting opportunity to explore new ways to support mental health through diet and gut health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals aged 18 or above
• • Patient Health Questionnaire-9 (PHQ-9) score between 5 to 14
• • Literate and can complete the self-report questionnaires
• • Able to understand the consent and sign the informed consent form
• Exclusion Criteria:
• • Current diagnosis of substance abuse or dependence;
• • A current or past history of bipolar disorder, manic or hypomanic episodes, schizophrenia, personality disorder, posttraumatic stress disorder (PTSD), intellectual disability, neurodegenerative disorders (e. g, Parkinson's disease) or organic mental disorder
• • Requiring immediate psychiatric care (e. g, imminently suicidal subjects) or have attempted suicide in the past 3 months
• • Use of antipsychotics, antidepressants or sedatives, unless on a stable dose in the last 4 weeks
• • History of severe organ failure, renal failure on dialysis, HIV infection
• • Active malignancy within 5 years
• • History of major surgery on the gastrointestinal tract, except cholecystectomy and appendectomy in the past 5 years
• • Night shift work
• • History of antibiotic use within 4 weeks
• • History of allergy to probiotics or lactose leading to a severe allergic reaction
• • Known pregnancy or lactating