A Study of Patients With Fabry Disease (US Specific)

Launched by AMICUS THERAPEUTICS · Mar 26, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a treatment called migalastat on patients with Fabry disease, a genetic condition that can lead to various health problems. The main goal of the study is to understand how well migalastat works over time, how safe it is, and how it affects the quality of life for patients. This is an observational study, meaning researchers will monitor patients who are already receiving migalastat or who are starting it, as well as some untreated patients, to see how their health changes.

To be eligible for the trial, participants need to be at least 18 years old and have a specific type of Fabry disease. They should either be currently taking migalastat or have never been treated for their condition. Participants will need to meet certain health criteria, like having a stable kidney function. During the study, participants can expect regular check-ups and assessments related to their health and treatment. This trial is not yet recruiting, but it aims to help improve care for people living with Fabry disease in the future.

Gender

ALL

Eligibility criteria

• • I. Migalastat-treated patients (Commercial only participants)
• • 1. Patients with Fabry disease 18 years or older with amenable GLA variants who have commenced commercial migalastat treatment within 24 months preceding enrollment, who have an eGFR greater than or equal to 30 mL/min/1.73 m2 at the time of enrollment and are still taking migalastat at the time of enrollment, or who are starting migalastat at the time of enrollment, excluding those who participated in a prior migalastat clinical trial
• 2. Patients who show a decline in their Fabry disease symptomatology based on any of the following:
• • 1. a decrease in annualized rate of decline eGFRCKD-EPI of ≥ 2 mL/min/1.73 m2 during the 2 years prior to enrollment
• • 2. microalbuminuria/macroalbuminuria (≥ 30 mg/24 h or ≥ 20 mg on first morning urine) or urine ACR of ≥ 30 mg/g (via spot urine collection) at any time prior to or at enrollment
• • 3. proteinuria (\> 0.5 g/g UPCR) any time prior to or at enrollment
• • 4. males with classic Fabry disease phenotype
• • II. Migalastat-treated patients who are not considered to be in renal decline (Commercial migalastat users only)
• • 1. Patients with Fabry disease with amenable GLA variants who have been on commercial migalastat regardless of the duration of treatment
• • III. Migalastat-treated patients (Prior clinical trial participants)
• • 1. Patients with Fabry disease 18 years or older who had commenced treatment with migalastat while in a clinical trial and were exposed to treatment for at least 24 months preceding enrollment, who have an eGFR greater than or equal to 30 mL/min/1.73 m2 at the time of enrollment, and who are still taking migalastat at the time of enrollment, having switched to commercial product
• • IV. Untreated patients
• • 1. Patients with Fabry disease 18 years or older with amenable GLA variants, who have never been on treatment for Fabry disease, who have an eGFR greater than or equal to 30 mL/min/1.73 m2 at the time of enrollment, and who meet local treatment guidelines for Fabry disease
• 2. Patients who show a decline in their Fabry disease symptomatology based on any of the following:
• • 1. a decrease in annualized rate of decline eGFRCKD-EPI of ≥ 2 mL/min/1.73 m2 during the 2 years prior to enrollment
• • 2. microalbuminuria/macroalbuminuria (≥ 30 mg/24 h or ≥ 20 mg on first morning urine) or urine ACR of ≥ 30 mg/g (via spot urine collection) at any time prior to or at enrollment
• • 3. proteinuria (\> 0.5 g/g UPCR) any time prior to or at enrollment
• • 4. males with classic Fabry disease phenotype
• • V. ERT-treated patients
• • 1. Patients with Fabry disease 18 years or older who have commenced ERT within 24 months preceding enrollment, who have an eGFR greater than or equal to 30 mL/min/1.73 m2 at the time of enrollment and are still being treated with ERT at the time of enrollment, and who have amenable GLA variants
• 2. Patients who show a decline in their Fabry disease symptomatology based on any of the following:
• • 1. a decrease in eGFRCKD-EPI annualized rate of decline of ≥ 2 mL/min/1.73 m2 during the 2 years prior to enrollment
• • 2. microalbuminuria/macroalbuminuria (≥ 30 mg/24 h or ≥ 20 mg on first morning urine) or urine ACR of ≥ 30 mg/g (via spot urine collection) at any time prior to or at enrollment
• • 3. proteinuria (\> 0.5 g/g UPCR) any time prior to or at enrollment
• • 4. males with classic Fabry disease phenotype
• • All patients 1. All treated and untreated patients with Fabry disease who are enrolled in the study must be able to understand and provide written informed consent or assent.
• • Exclusion Criteria
• • 1. Patients who currently are participating in a clinical trial of any investigational medicinal product or device at the time of enrollment