Physiological Responses to Heat Stress During High-risk Events

Launched by UNITED STATES ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE · Mar 31, 2025

Keywords

ClinConnect Summary

Exertional heat stroke (EHS) affects \~500 Military Personnel (MSMR, 2022) and over 100 Soldiers (Giersch et al, 2022) every year. EHS is the most severe form of exertional heat illness and can result in substantial, long-lasting organ damage and sometimes death. While some risk factors for EHS are known (Roberts et al, 2021), and the investigators have effective treatments available (Caldwell et al, 2022), EHS cases are not 100% preventable. Furthermore, it is not possible to investigate EHS directly in the laboratory, as safety criteria limit the core temperatures (Tcore) permitted. There...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Individuals (to include cis- and transgender males and females and nonbinary) 18 years of age or greater
• • Current military service (active, Reserve, or National Guard)
• • Currently participating in training
• Exclusion Criteria:
• • Females who are pregnant
• • Any individual currently on a physical profile that restricts running or foot marching
• • History of obstructive disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis.
• • Scheduled MRI within 2 weeks after core temp pill ingestion
• • Known allergies to skin adhesive
• • Blood donation in the past 8 weeks