Photoacoustic/Ultrasound Imaging for Breast Nodule Diagnosis, Molecular Classification, and Neoadjuvant Chemotherapy Response Evaluation

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Mar 26, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring a new imaging technique called photoacoustic imaging (PAI), which combines light and sound to help doctors better understand breast tumors. The main goals of the study are to create a system that can help distinguish between benign (non-cancerous) and malignant (cancerous) tumors, to identify the specific type of cancer in malignant tumors, and to assess how well neoadjuvant chemotherapy (treatment given before surgery) is working. Participants in the trial will undergo PAI and ultrasound imaging at four different times during their chemotherapy treatment to see how effective this new imaging method can be.

To participate in this trial, women aged 18 and older who have a breast tumor that can be seen on a standard ultrasound and have had a biopsy or surgery within the past week may be eligible. However, those who are pregnant, breastfeeding, or have certain other conditions may not qualify. If you join this study, you can expect to have regular imaging tests to help track your treatment and provide valuable information for future breast cancer diagnosis and treatment.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. The patients were above 18 years-old;
• • 2. The patients were presented with a breast tumor, which were clearly shown on routine ultrasound; Biopsy or surgery of breast lesions was performed within 1 week and pathological diagnosis was obtained.
• • 3. Patients agreed to participate in this experiment and signed the Subject Informed Consent.
• Exclusion Criteria:
• • 1. Pregnant or lactating women;
• • 2. Breast inflammation or local external injury;
• • 3. The breast mass has been excised for biopsy.
• • 4. Poor photoacoustic imaging effect.
• • 5. Deep lesion location (\>3.5 cm)