Effects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patient-Reported Outcomes After Total Knee Arthroplasty

Launched by REGIONSHOSPITALET SILKEBORG · Apr 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different amounts of local anesthetic (Bupivacaine) used during a specific nerve block (called a Popliteal Plexus Block) to help manage pain after total knee replacement surgery. The trial compares using 10 mL versus 20 mL of the anesthetic to see which amount can better reduce the need for opioid pain medications in the first 24 hours after surgery. Researchers will also look at how much pain participants have, their ability to move around, and their overall recovery experience.

To participate in this study, individuals must be scheduled for total knee arthroplasty, be able to give informed consent, and have a general health status that falls within certain guidelines. Participants will receive either 10 mL or 20 mL of the anesthetic and will also have access to a multimodal pain management plan, which includes other pain-relief methods. After the surgery, they will be assessed by a physiotherapist to check their pain levels and mobility, and they will fill out a survey to share their experiences. It’s important to note that individuals with certain health conditions or those who cannot engage with the study requirements may not be eligible to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Scheduled to undergo primary total knee arthroplasty in spinal anesthesia.
• • Ability to give their written informed consent after having fully understood the contents of the study.
• • American Society of Anesthesiologists (ASA) physical status 1, 2, or 3.
• Exclusion Criteria:
• • Patients who cannot read or speak Danish.
• • Patients who cannot operate or have access to a smartphone with internet connectivity (required for patient-reported outcome assessment).
• • Patients with allergies or intolerance to the medicines used in the study.
• • Patients with a consistent daily intake of opioids preoperatively.
• • Patients who are dependent on walking aid devices preoperatively.
• • Patients suffering from alcohol and/or drug abuse - based on the investigator's assessment.
• • BMI \> 40.
• • Diagnosed with chronic neurodegenerative disorders.