Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease

Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · Mar 27, 2025

Keywords

ClinConnect Summary

The CLOSE-PD study is a research trial designed to compare two types of deep brain stimulation (DBS) treatments for people with Parkinson's disease: adaptive deep brain stimulation (aDBS) and continuous deep brain stimulation (cDBS). The main goal is to find out if aDBS can help patients have more active, enjoyable time during the day without the troublesome side effects known as dyskinesia (involuntary movements) compared to cDBS over a period of six months.

To participate in this study, individuals must be 18 years or older, have a confirmed diagnosis of Parkinson's disease, and have already had specific brain electrodes implanted for treatment. They also need to be able to speak and understand Dutch. Participants will be divided into two groups, with one group receiving aDBS and the other cDBS. Over the six months, they will keep a diary to track their symptoms and experiences at different points in the study. It’s important to know that this study is not currently recruiting participants, but it aims to help improve treatment options for people living with Parkinson's disease in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of idiopathic PD based on the UK Brain Bank criteria (Hughes et al. 1992);
• • Age older than 18 years;
• • Previous implantation of Medtronic PerceptTM PC/RC DBS electrodes bilateral targeting the STN;
• • Reliable beta peak in at least one STN;
• • Able to provide informed consent and comply with the study protocol;
• • Understand the Dutch language.
• Exclusion Criteria:
• • Legally incompetent adults;
• • Patients with ongoing participation in other clinical trials involving neurological interventions;
• • Inability to recognize the difference between the motor ON or OFF state;
• • Mild cognitive impairment or dementia;
• • Pregnancy.