Hypotension Prediction Index and Intraoperative Hypotension Incidence

Launched by FIRST AFFILIATED HOSPITAL XI'AN JIAOTONG UNIVERSITY · Mar 27, 2025

Keywords

ClinConnect Summary

The clinical trial titled "Hypotension Prediction Index and Intraoperative Hypotension Incidence" is studying a new way to monitor and manage blood pressure during surgery, specifically in older patients who may be frail. The researchers believe that using a special algorithm called the Hypotension Prediction Index (HPI) will help doctors better treat low blood pressure during surgery, potentially leading to fewer complications after surgery, such as kidney issues and recovery problems with the intestines.

To participate in this trial, individuals must be over 60 years old, have a certain level of frailty, and be scheduled for major abdominal surgery that requires general anesthesia and will last more than three hours. Participants will be monitored closely during their surgery with an arterial line to track their blood pressure. It's important to note that some patients may not be eligible, especially if they have severe heart issues or uncontrolled high blood pressure. This study is not yet recruiting participants, but it aims to improve surgical care for older adults by reducing the risks associated with low blood pressure during operations.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age\> 60 years old
• • Frail score \> 2
• • ASA≥2
• • Planned to receive general anesthesia
• • Elective laparoscopic or laparotomy major abdominal surgery with an expected duration of \> 180 minutes
• • Planned to receive an arterial line monitoring intraoperatively
• • Being able to give written informed consent prior to surgery
• Exclusion Criteria:
• • Severe cardiac arrhythmia including atrial fibrillation
• • Severe aortic stenosis
• • Uncontrolled Hypertension (sitting systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥100 mmHg during screening)
• • Significant hypotension before surgery defined as a MAP \<65mmHg
• • Chronic kidney disease with glomerular filtration rate \<30 ml/min/1.73 m2 or requiring renal-replacement therapy for end-stage renal disease
• • Organ transplant surgery, surgery involving the kidney, liver surgery requiring hilar blockage, surgery requiring controlled hypotension or controlled low central venous pressure