Association of Sarcopenia With Rocuronium Use in Liver Transplant Recipients

Launched by INONU UNIVERSITY · Mar 27, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the relationship between sarcopenia, which is a condition characterized by muscle loss, and the use of a medication called rocuronium in patients who are undergoing liver transplant surgery. The goal is to better understand how muscle health may affect the use of this medication during the procedure. Eligible participants are adults over the age of 18 who are candidates for a liver transplant and are in good enough health to undergo surgery. However, those with certain conditions, such as severe kidney or heart problems, or those who cannot give consent, will not be included.

If you participate in this trial, you'll be asked to give your consent when you arrive in the operating room. Before the surgery, some basic health information will be collected, including your age, gender, and results from various tests. During the surgery, your muscle strength will be measured, and some routine monitoring will take place to keep track of your health. The researchers will also observe how well the medication works throughout the procedure and note any important details related to your recovery, such as how long you need to stay in the hospital.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with American Society of Anesthesiologists (ASA) 2-3,
• • Patients over the age of 18,
• • Liver transplant recipient candidates who have agreed to receive an organ transplant
• Exclusion Criteria:
• • Patients who are unconscious enough to not be included in the study (patients for whom consent cannot be obtained and the study cannot be explained)
• • Patients under the age of 18
• • Patients aged 65 and over
• • Patients with advanced renal failure
• • Patients with massive ascites in the abdomen
• • Patients with advanced heart failure or high pulmonary artery pressure for whom routine anesthesia induction protocols must be excluded
• • Patients with psychosis or substance abuse Patients with a known adverse reaction to rocuronium
• • Patients with indications for rapid sequence intubation