Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle: Impact of Hormonal Fluctuations on Healthy Women Undergoing Ovarian Stimulation
Launched by ART FERTILITY CLINICS LLC · Apr 2, 2025
Trial Information
Current as of July 09, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring how hormonal changes during different phases of the menstrual cycle affect brain activity in healthy women. The researchers want to compare the brain's responses in women who are having their natural menstrual cycles with those undergoing an ovarian stimulation procedure, which involves taking hormones to encourage the ovaries to produce eggs. Using a type of brain imaging called resting-state fMRI, they will observe how brain activity varies across different phases, such as before and after egg retrieval and during the natural cycle.
To participate in this study, women aged 25 to 35 who have a regular menstrual cycle and meet specific health criteria may be eligible. Participants should have a healthy body weight and certain hormone levels, and they should not have a history of ovarian surgery or mental health disorders. If you join this study, you can expect to undergo brain imaging during different hormonal phases, helping researchers understand how these changes impact brain function. This research could provide valuable insights into women's health and how hormonal treatments affect the brain.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Age group: 25 - 35 years old
- • BMI: 20 - 30
- • Anti-Mullerian Hormone (AMH): 1.3 - 5.9 ng/ml
- • Regular Menstrual Cycle: 26-35 days
- • In case of previous use of hormonal contraception: wash-out period of 3 month
- • Meet standard safety and eligibility criteria for MRI scanning, including the absence of contraindications such as metallic implants, claustrophobia, or other medical conditions that preclude MRI
- Exclusion Criteria:
- • History of ovarian surgery
- • Pathology of the ovaries
- • Mental health disorders
- • Use of medication influencing brain function
- • Ongoing use of hormonal contraception (this would include OCP, but also patches and Mirena containing IUD)
About Art Fertility Clinics Llc
Art Fertility Clinics LLC is a leading provider of advanced reproductive healthcare services, specializing in assisted reproductive technologies to support individuals and couples facing fertility challenges. With a commitment to personalized care, state-of-the-art facilities, and a team of experienced specialists, the clinic offers a comprehensive range of services, including in vitro fertilization (IVF), egg freezing, and genetic testing. Art Fertility Clinics LLC is dedicated to advancing reproductive science through innovative clinical trials and research initiatives, ensuring patients receive the most effective and up-to-date treatment options available.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Abu Dhabi, , United Arab Emirates
Abu Dhabi, , United Arab Emirates
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported