Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy

Launched by CAIRO UNIVERSITY · Mar 28, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different medications, dexmedetomidine and lidocaine, to see which one helps manage chronic pain better after women have surgery for breast cancer, specifically mastectomy. Both of these medications will be given along with general anesthesia, which is the medicine that makes patients sleep during surgery. The goal is to find out which option provides better pain relief after the surgery.

To participate in this trial, women aged 18 to 75 who are scheduled for a mastectomy with axillary dissection (a procedure often done to remove breast tissue and check for cancer) may be eligible. However, those who refuse to participate, have allergies to the study drugs, or have certain health conditions, like liver or kidney problems, won't be able to join. If someone decides to participate, they can expect to receive either dexmedetomidine or lidocaine during their surgery and will be monitored closely for pain after the procedure. This trial is currently recruiting participants, and it's an opportunity to potentially help improve pain management for future patients.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age from 18 to 75 years.
• • American Society of Anesthesiologists (ASA) physical status II.
• • Scheduled for mastectomy with axillary dissection (either modified radical mastectomy with or without latissimus dorsi flap or conservative breast surgery) due to breast cancer.
• Exclusion Criteria:
• • Patient refusal.
• • Known allergy to any of the study drugs.
• • Those with hepatic or renal insufficiency.
• • Patients who are running regularly on B blockers.
• • α2 adrenergic agonists and sedatives.
• • Psychoactive medications.