Yeast Mannans and Stool Frequency

Launched by UNIVERSITY OF FLORIDA · Apr 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a daily supplement of yeast mannans can help increase the number of times people have a bowel movement, specifically for adults who typically have one or fewer stools a day. In earlier research, taking yeast mannans was found to be safe and may have helped some participants have more frequent bowel movements. The main goal of this study is to see if a 12-gram daily dose of yeast mannans can improve stool frequency in generally healthy adults who are having difficulty with regular bowel movements.

To participate, you must be an adult who has one or fewer bowel movements each day and be willing to take either the yeast mannan supplement or a control supplement for 28 days. You should also be able to follow the study rules, which include maintaining your usual diet and activity level while avoiding yeast-based foods. However, individuals with certain health conditions, such as yeast allergies or intestinal diseases, or those currently taking specific medications, may not be eligible. If you decide to join, you will be asked to provide some urine and stool samples during the trial to help researchers understand how the yeast mannans affect your body.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults who report a stool frequency of ≤ 1 per day.
• • Able to provide written informed consent in English.
• • Willingness to consume 1 supplement (12 g of yeast mannans or control) daily for 28 days.
• • Willingness to maintain their usual diet and physical activity patterns throughout the study and refrain from the consumption of any yeast-based foods (e.g. Marmite or Vegemite) or yeast extract supplements.
• • Willing to comply with study procedures, including stool and urine colle
• Exclusion Criteria:
• • Stool frequency of \< 3 per week
• • Yeast allergy
• • Vegan dietary pattern
• • Self-reported kidney disease
• • Elite athletes or long-distance runners
• • Use of antibiotic drugs within 1 month of screening
• • Current use of laxatives or antidiarrheal medications
• • Use of other investigational products within 3 months of the screening
• • Previously or currently being treated for intestinal diseases or conditions, including irritable bowel disease (i.e., IBS-D or IBS-mixed), Crohn's disease, ulcerative colitis, celiac disease, or gastrointestinal cancer.
• • Previous gastrointestinal surgery (e.g., gastric bypass, fundoplication, bowel resection).
• • Current cancer treatment.
• • Currently pregnant.