From Inflammation to Remodelling Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19

Launched by UNIVERSITY MEDICAL CENTER GRONINGEN · Apr 3, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a condition known as long COVID, which can cause ongoing symptoms like shortness of breath (dyspnea) and fatigue even after recovering from COVID-19. The researchers want to understand if certain activity in the lungs, measured using a special imaging technique called PET/CT, is different in people still experiencing these symptoms compared to those who have fully recovered. By studying 60 adults—half of whom have long COVID symptoms and half who have recovered—the team hopes to learn more about the causes of long COVID and how to diagnose it better.

To participate, individuals need to have experienced ongoing shortness of breath or fatigue for more than three months after a confirmed COVID-19 infection. However, those who are pregnant, breastfeeding, or have issues with anxiety in confined spaces won’t be eligible. Participants can expect to spend a day at the study site undergoing various tests, including questionnaires, lung function assessments, and the PET/CT scan. This research is important as it aims to provide insights that could lead to better treatment and understanding of long COVID.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Self-reported complaints of dyspnea or fatigue \> 3 months after SARS-CoV-2 infection confirmed with PCR, serology test or COVID-19 Reporting and Data System (CO-RADS) score 4/5.
• Exclusion Criteria:
• • Inability or unwilling to give informed consent.
• • History of claustrophobia or feeling of inability to tolerate supine position for the PET/CT scans.
• • Individuals who are pregnant or currently breastfeeding are not eligible to participate