Impact of Nutritional Management on the Frailty of Patients Waiting for Liver Transplantation (Via the LFI Tool)

Launched by HOSPICES CIVILS DE LYON · Mar 28, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how nutritional support can affect the health of patients who are waiting for a liver transplant. Many patients with severe liver disease, known as cirrhosis, can become weak and malnourished while they wait for a transplant. The study will use a special tool called the Liver Frailty Index (LFI) to assess how fragile these patients are. The researchers want to see if regular follow-ups with a dietitian, who is an expert in nutrition for liver patients, can help improve their strength and overall health compared to standard care without specific dietary guidance.

To participate in the study, patients must be at least 18 years old, currently on the liver transplant waiting list, and able to perform some simple exercises to measure their strength. The trial will include around 210 patients over two years, and all participants will have their frailty levels checked at three and six months. This study aims to find out if better nutrition can make a difference in how patients feel and their chances of getting a transplant, helping doctors understand the best ways to support patients during this critical time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient aged ≥ 18 years
• • Patient registered on the waiting list for Hepatic Transplantation in the Transplantation center of the Croix Rousse Hospital (GHN), Hospices Civils de Lyon
• • Dated and signed an informed consent
• • Affiliated to a social security scheme or beneficiary of a similar scheme
• Exclusion Criteria:
• • Patient hospitalized in intensive care
• • Patient with initial LFI test result \< to 3.2, that is considered as "robust".
• • Patient unable to perform LFI exercises (chronic or acute motor disability in lower or upper limbs)
• • Pregnant, parturient or lactating women
• • Persons deprived of liberty by a judicial or administrative decision
• • Persons under psychiatric care
• • Persons admitted to a health or social institution for purposes other than research
• • Adults subject to a legal protection measure (guardianship, curatorship)
• • Inability to understand protocol information
• • Subject participating in another interventional research including an ongoing exclusion period at inclusion