Continous Positive Airway Pressure (CPAP) Support for Acute Hypoxemic Respiratory Failure in Burkina Faso

Launched by UNIVERSITÉ NAZI BONI · Mar 30, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the use of a treatment called Continuous Positive Airway Pressure (CPAP) for patients with acute hypoxemic respiratory failure, which is a serious condition where the lungs can't provide enough oxygen to the body. In many low-income countries, invasive treatments like ventilators are not always available, so researchers want to see if CPAP can help patients breathe better without needing more invasive support. CPAP has been shown to reduce the need for intubation (inserting a tube down the throat to support breathing) during the COVID-19 pandemic, making it a practical option for those in need.

To participate in this trial, individuals must be at least 18 years old and meet certain health criteria, such as having difficulty breathing or needing a lot of oxygen to maintain good oxygen levels in their blood. However, some people won't be able to join, including those who are pregnant, have certain severe health conditions, or are unable to give consent. Participants in the trial can expect to receive CPAP treatment and will be closely monitored by medical staff. This trial aims to find a safe and effective way to help patients with breathing difficulties, especially in settings where advanced medical equipment is limited.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• All patients aged 18 years and older will be included in the study if they meet at least one of the following criteria :
• • Acute respiratory distress, defined as dyspnea respiratory rate ≥ 25 cycles/min
• • Hypoxemia, defined as the need for more 6 liters of oxygen to maintain an oxygen saturation (SpO2) of ≥ 92%. The fraction of inspired oxygen (FiO2) will be estimated using the 3% rule.
• Exclusion Criteria:
• Patients with any of the following criteria will not be included in the study:
• • Pregnant or breastfeeding women
• • Persons deprived of their liberty
• • Exacerbation of asthma, chronic obstructive pulmonary disease, or another chronic respiratory disease
• • Moderate to large amount of unilateral or bilateral undrained pleural effusion
• • Contraindication to CPAP: patient refusal, undrained pneumothorax, chest injury, repeated or large vomiting, upper gastrointestinal bleeding, craniofacial trauma, severe upper airway obstruction, or tetraplegia in the initial phase
• • Cardiac arrest, severe arrhythmias, shock requiring the use of vasopressors (norepinephrine, adrenaline, dopamine)
• • Altered level of consciousness (Glasgow Coma Scale score \< 13), repeated seizures, or status epilepticus
• • Medical decision to limit treatment: no intubation, no admission to intensive care
• • Refusal to participate in the study or participation in another interventional study on respiratory distress or acute respiratory failure.