Comparative Efficacy of Lipid Based Artificial Tears vs Aqueous Based Artificial Tears in Managing EDE

Launched by SUPERIOR UNIVERSITY · Mar 29, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two types of artificial tears to see which one works better for people with Evaporative Dry Eye (EDE). The trial compares lipid-based artificial tears (called Recuro) and aqueous-based artificial tears (called Softeal) over a period of six weeks. It includes 60 adults, aged 18 to 55, who have been diagnosed with EDE and have experienced dry eye symptoms for at least 1 to 3 months. To be eligible, participants should have a score that shows they have mild to severe dry eye symptoms and a test result indicating their tears are not lasting long enough.

If you join this trial, you will be asked to use one of the two types of artificial tears as part of your treatment. It's important to know that you cannot use other eye medications or wear contact lenses during this study. The goal is to find out which type of artificial tear helps relieve symptoms better, which can ultimately improve comfort and quality of life for those dealing with dry eyes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (both genders) aged 18-55 years diagnosed with evaporative dry eye (EDE).
• • Willingness to adhere to the prescribed treatment regimen (lipid-based or aqueous-based artificial tears).
• • Include patients with a history of dry eye symptoms for at least 1-3 months.
• • Ocular Surface Disease Index (OSDI) score ≥13, indicating the presence of mild to severe dry eye symptoms.
• • Patients with tear break-up time (TBUT) \<10 seconds, indicating tear film instability.
• Exclusion Criteria:
• • Use of any topical ophthalmic medications (e.g., lubricants, anti-inflammatory drugs, or cyclosporine) for dry eye within the last 1 month.
• • Active ocular infection or inflammation (e.g., conjunctivitis, uveitis).
• • History of ocular surgery or trauma within the past 6 months.
• • Participants currently wearing contact lenses or those who have worn contact lenses in the past three months.
• • Systemic conditions known to impact ocular surface health, such as uncontrolled diabetes, autoimmune disorders, or Sjögren's syndrome.