Evaluation of Corneal Epithelial Mapping in Diagnosis of Early Keratoconus by Anterior Segment Optical Coherence Tomography

Launched by ASSIUT UNIVERSITY · Apr 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new method to detect early signs of keratoconus, a condition where the cornea (the clear front part of the eye) becomes thin and bulges, causing vision problems. The researchers are using a special imaging technology called Anterior Segment Optical Coherence Tomography (AS-OCT) to measure the thickness of the corneal epithelium, which is the outer layer of the cornea. By identifying changes in this thickness before noticeable signs of keratoconus appear, the study aims to improve early diagnosis and treatment options, potentially helping to slow down the progression of the disease.

To participate in the trial, individuals must be at least 18 years old. They can either be healthy adults planning to have LASIK surgery, or patients already diagnosed with keratoconus. Those who may have suspicious signs of keratoconus based on previous tests, like pentacam imaging, are also eligible. However, people with a history of corneal surgery, active eye infections, or conditions that affect the cornea will not be included. Participants can expect to undergo detailed eye imaging procedures that are designed to gather important information about their corneal health, contributing to better understanding and management of keratoconus.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Healthy participants with normal corneal topography and no ocular abnormalities intended to do LASIK.
• • Keratoconus patients with a confirmed diagnosis (based on corneal topography, tomography, and clinical signs).
• • Suspicious Keratoconus patients by pentacam.
• • Age ≥ 18 years.
• • Willingness to provide informed consent.
• Exclusion Criteria:
• • • History of corneal surgery or trauma.
• • Active ocular infection or inflammation.
• • Severe dry eye disease or other conditions affecting corneal epithelium.
• • Inability to cooperate with imaging procedures.