Personalised Treatment for OSA

Launched by UNIVERSITY HOSPITAL, ANTWERP · Apr 3, 2025

Keywords

ClinConnect Summary

This is an ongoing, real-world study called “Personalized Treatment for Obstructive Sleep Apnea: Beyond CPAP,” based at University Hospital, Antwerp in Belgium. It’s an observational, prospective cohort study that will follow adults with moderate to severe obstructive sleep apnea (OSA) who cannot tolerate or don’t use CPAP. The goal is to collect information over about 5 years from routine care to see how well alternative treatments work in everyday practice. The study plans to enroll about 850 participants and will use a drill-down approach (including a sleep-endoscopy test called DISE) to understand airway collapse and tailor future care.

People who may be eligible are adults aged 18 and older with an AHI of 15 or higher (moderate to severe OSA) who are CPAP-intolerant or non-compliant and are willing to explore other options. Key details you might want to know: the main outcome being tracked is the apnea-hypopnea index (AHI) from baseline to about 3 months and 12 months to see how sleep-disordered breathing changes. Secondary information includes why CPAP was stopped, daytime sleepiness (via the Epworth Sleepiness Scale), disease-specific quality of life, changes in snoring, and baseline DISE findings to guide treatment. Participants will not be on a single fixed treatment; the study aims to document and compare how different approaches work in real life, helping doctors personalize care for CPAP-intolerant patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • adult patients (age starting from 18 years old)
• • moderate to severe OSA (AHI ≥ 15/h)
• • CPAP-intolerant or non-compliant
• • willing to explore alternative treatment options
• Exclusion Criteria:
• • patients who are still on CPAP therapy
• • pediatric patients
• • newly diagnosed patients who have not had CPAP before
• • patients with AHI ≥ 65 events/h.