Danish Prognostic Research on Embryonic Diagnostics Involving Chromosomal Testing.

Launched by CHRISTIAN LIEBST FRISK TOFT · Apr 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a method called preimplantation genetic testing for aneuploidy (PGT-A), which aims to check embryos for chromosomal abnormalities before they are implanted. The goal is to help doctors choose the best embryos for transfer, potentially reducing the chances of miscarriage and increasing the likelihood of a healthy pregnancy. The study will look at two ways to obtain DNA for testing: through a small sample taken from the embryo itself and from the culture media where the embryo has grown. By analyzing this information, researchers hope to determine if PGT-A can improve the success rates of fertility treatments.

To participate in this study, individuals must be undergoing preimplantation genetic testing for specific genetic disorders (known as PGT-M). There are no specific exclusions based on other health conditions. Participants can expect to have their embryos tested as part of standard care, and the study will track the outcomes of embryo transfers to see if the testing truly helps predict which embryos are likely to lead to a live birth. The trial is expected to recruit around 220 patients over two years across two centers in Denmark. Importantly, any additional genetic tests during pregnancy will be optional and require consent.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Undergoing preimplantation genetic testing for monogenic disorders (PGT-M)
• Exclusion Criteria:
• • None