Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents

Launched by UNIVERSITY OF AVIGNON · Mar 31, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a dietary supplement made from capsinoids, which are found in sweet peppers and chillies, can help activate brown adipose tissue (BAT) in obese adolescents. BAT is a special type of fat that helps burn energy and produce heat, which could be beneficial for weight management. Researchers believe that by combining capsinoid supplements with a healthy diet, they can increase the activity of BAT and potentially help these young participants lose weight.

To be eligible for this trial, participants must be between the ages of 11 and 18, have a certain level of obesity, and not have lost more than 5% of their weight in the last three months. The study is open to all genders. Participants will be randomly assigned to receive either the capsinoid supplement or a placebo (a non-active pill) for comparison. It’s important for families to know that the study is currently recruiting participants, and everyone involved will be informed about the study’s purpose and procedures before agreeing to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • member or beneficiary of a health insurance scheme
• • aged between 11 and 18
• • Body Mass Index Z score corresponding to stage 2 obesity according to the curves of Rolland-Cachera et al., 1991 and an absence of weight loss of more than 5% of the total weight over the last 3 months.
• • effective contraception (in pubescent females)
• Exclusion Criteria:
• • known allergy to capsinoids and/or soya
• • inflammatory digestive pathology and/or history of digestive tract surgery
• • participation in another study or in a period of exclusion determined by a previous study
• • pregnant, parturient or breastfeeding
• • The holder(s) of parental authority or the adolescent refuse(s) to sign the authorisation or acceptance form, respectively.
• • It proves impossible to provide the adolescent or parental guardian(s) with informed information.