Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1

Launched by MEDICAL UNIVERSITY OF GDANSK · Apr 5, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a stronger dose of the medication omeprazole can help reduce the amount of output from an ileostomy, which is a surgical opening created to help patients with certain bowel conditions, like colon cancer or inflammatory bowel disease (IBD). The goal is to see if this intensified treatment can lower the daily output of waste, prevent dehydration-related issues, and lead to a quicker recovery after surgery. Participants will receive either the standard dose of omeprazole or a higher dose while they are in the hospital, and their ileostomy output will be measured daily.

To join this study, participants need to be at least 18 years old and scheduled for surgery to create an ileostomy. They must be able to give consent and not have any conditions that would prevent accurate measurement of their ileostomy output. During the trial, participants will have regular check-ups to monitor their health and electrolyte levels, both while in the hospital and for up to 30 days after they go home. This study aims to find out if the higher dose of omeprazole can improve recovery and overall health for patients undergoing this type of surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged 18 years or older
• • Scheduled for elective or emergency surgery requiring end or loop ileostomy formation
• • Able and willing to provide written informed consent
• • No contraindications to omeprazole use
• Exclusion Criteria:
• • Pregnancy or lactation
• • Known hypersensitivity or allergy to proton pump inhibitors (including omeprazole)
• • Conditions preventing accurate measurement of daily ileostomy output