Ultrasonographic Evaluation of the Effects of Different Wrist Positions on the Median Nerve in Patients With Generalized Joint Hypermobility

Launched by ISTANBUL PHYSICAL MEDICINE REHABILITATION TRAINING AND RESEARCH HOSPITAL · Apr 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different wrist positions—like bending, straightening, or tilting the wrist—affect the median nerve in women diagnosed with generalized joint hypermobility (GJH). The researchers want to see if the median nerve changes shape or flexibility when the wrist is moved in these ways, and they will compare the results with those from healthy women without GJH.

To participate in this study, you must be a woman aged 15 to 45 who has been diagnosed with GJH. You should be able to move your wrist fully and not have any pain or certain medical conditions that could affect your hand or wrist. If you join the study, you will undergo an ultrasound, a painless imaging test, to evaluate your median nerve while your wrist is in different positions. This research aims to better understand how GJH affects nerve function, which could help improve care for those with this condition.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 15-45 years of age
• • Female gender
• • Diagnosed with GJH according to the hypermobility spectrum disorders definition
• • Patients who agree to participate in the study and provide written consent
• Exclusion Criteria:
• • Having wrist pain
• • Inability to complete full range of motion in the wrist joint
• • Patients diagnosed with carpal tunnel syndrome
• • Anatomical abnormalities (bifid median nerve, aberrant persistent median artery, Martin-Gruber or other anastomoses)
• • History of trauma, operation, fracture, or steroid injection of the hand/wrist
• • History of known rheumatological, hereditary, genetic disease, or connective tissue disease other than GJH
• • Having neurological disease affecting hand functions (cervical radiculopathy, peripheral nerve lesion, polyneuropathy, cerebrovascular event, etc.)
• • Patients with history of regular steroid or non-steroid use, receiving oral glucosamine/hyaluronate supplementation
• • Those with systemic diseases (inflammatory joint diseases, diabetes mellitus, acromegaly, hypothyroidism, kidney failure, etc.)
• • Having a body mass index (BMI) of 30 or above, or history of morbid obesity
• • Being pregnant or in lactation period
• • Presence of malignancy