Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation

Launched by CENTRE FOR MEDICAL SCIENCES · Apr 2, 2025

Keywords

ClinConnect Summary

The TEMA study is looking at how to improve breathing support for patients with serious lung issues, specifically those who are receiving mechanical ventilation due to acute hypoxemic respiratory failure (AHRF). Researchers want to understand how to set the right level of ventilatory support by using a measure called the Pressure-Muscle Index (PMI). The goal is to find a balance that helps patients breathe better without giving them too much assistance, which can lead to problems like muscle weakness in the diaphragm or lung injuries.

To participate in this study, individuals must be at least 18 years old, be in the ICU on mechanical ventilation for AHRF, and have certain blood gas measurements. They should also have an arterial line for easy blood sampling. The study is not yet recruiting participants, but it will involve carefully monitoring how changes in ventilatory support can be tailored to each patient's needs. This research could help make breathing support safer and more effective for people facing serious lung challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years
• • 2. Mechanically ventilated in the ICU
• • 3. Diagnosis of Acute Hypoxemic Respiratory Failure (AHRF)
• • 4. Normocapnia or non-severe hypercapnia
• • 5. Receiving Pressure Support Ventilation (PSV) for at least 24-72 hours
• • 6. Presence of an arterial line for blood gas sampling
• Exclusion Criteria:
• • 1. Age \< 18 years
• • 2. Known neurological or neuromuscular disorders affecting diaphragm function
• • 3. Chronic Obstructive Pulmonary Disease (COPD) or hypercapnic respiratory failure
• • 4. Psychomotor agitation or inadequate sedation