Changes in the Urinary Microbiome and Metabolome During Treatment of the Overactive Bladder in Female Patients

Launched by UNIVERSITY HOSPITAL OSTRAVA · Apr 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how the urinary microbiome (the community of microbes in the urine) and metabolome (the small molecules produced by these microbes) change during treatment for Overactive Bladder (OAB) in women. OAB is a condition that causes a sudden and strong urge to urinate, often leading to frequent trips to the bathroom. The trial will not involve any new treatments or procedures; instead, it will collect urine samples that are already part of the regular care process to better understand how these changes relate to OAB symptoms.

To participate in the study, women must be over 18 years old and have been experiencing OAB symptoms for more than three months, with at least three episodes of significant urgency documented in a diary. They should also be willing to undergo standard evaluations and treatments for OAB. However, women with certain conditions, such as previous treatments for OAB, recurrent urinary tract infections, or specific urinary tract abnormalities, won't be eligible. Participants can expect to receive standard care while contributing to valuable research that may help improve treatment options for OAB in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Adult women over 18 years of age
• • Written consent to participate in the study
• • Willingness to undergo OAB evaluation and treatment according to the protocol
• • OAB symptoms lasting longer than 3 months
• • At least 3 episodes of severe urgency with or without urge incontinence within 3 days documented by voiding diary
• • OAB symptom score V8 questionnaire ≥ 8
• Exclusion Criteria:
• • Known congenital developmental defects of the urinary tract (congenital hydronephrosis, vesicoureteral reflux, renal agenesis and hypoplasia, multicystic and polycystic kidneys)
• • Any previous treatment for OAB
• • Recurrent urinary tract infections (more than 3 episodes in the last 12 months)
• • Presence of a foreign body in the urinary tract - urolithiasis, urinary catheter, ureteral stent
• • Acute or chronic diseases with possible influence on the function of the lower urinary tract (LUT)
• • Rheumatoid arthritis
• • Diabetes mellitus