PET/CT GUIDED BIOPSY VERSUS CT GUIDED BIOPSY IN EVALUATION OF SUSPECTED LUNG NEOPLASMS

Launched by ALL INDIA INSTITUTE OF MEDICAL SCIENCES, BHUBANESWAR · Apr 4, 2025

Keywords

ClinConnect Summary

This clinical trial is comparing two different methods for obtaining tissue samples from suspected lung tumors: PET/CT guided biopsy and traditional CT guided biopsy. The researchers want to see which method is better at accurately diagnosing lung cancer and which has fewer complications. PET/CT guided biopsy is thought to be more effective because it can pinpoint the areas with the highest concentration of cancer cells, which may lead to clearer results than the standard method.

To participate in this study, individuals must be at least 18 years old and have a lung lesion larger than 10 millimeters that can be reached for a biopsy. They should also have normal blood clotting levels. However, people with certain bleeding disorders, those who are pregnant or breastfeeding, and those with specific health issues like low oxygen levels or kidney problems cannot participate. If eligible, participants will undergo one of the biopsy methods and will be monitored for any side effects. This trial is currently recruiting participants, and it aims to improve how doctors diagnose lung diseases in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age above 18 years
• • INR \< 1.2 and platelet counts \> 80,000/mm3
• • CT thorax with lung lesion more than 10 mm.
• • Accessible lesions for CT-guided biopsy.
• Exclusion Criteria:
• • Participants with pre-existing bleeding diathesis like hemophilia, coagulopathy defined by -INR ≥1.2 and Platelet counts ≤ 80,000/mm3
• • Participants who refuse to provide consent
• • Signs of hypoperfusion like hypotension, cyanosis etc.
• • Presence of hypoxemia with SpO2 \< 94 %- measured in a pulse oximeter)
• • Pregnant/Lactating female subjects
• • Non-cooperative subjects
• • Lesions that are inaccessible (decision made on pre-biopsy planning)
• • Serum creatinine level more than 2mg/dl.