Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials

Launched by CENTRE HOSPITALIER RÉGIONAL D'ORLÉANS · Apr 9, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how well the heart functions during different breathing tests in adults who are on a ventilator in the Intensive Care Unit (ICU). The goal is to find out which breathing test puts the least strain on the heart, especially for patients who may have trouble breathing on their own. Researchers will use heart ultrasound measurements while patients try breathing without help from the ventilator during three different tests.

To be eligible for this study, participants need to be adults over 18 years old who have been on a ventilator for at least 24 hours and are scheduled to try breathing on their own. They should also be at high risk for needing the ventilator again due to heart or lung problems. During the study, participants will not have to do anything extra apart from the breathing tests, and the researchers will take care of all the necessary heart checks. This trial is not yet recruiting participants, but it aims to provide important insights into safer ways to help patients breathe independently.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Intubated patient undergoing invasive mechanical ventilation for at least 24 hours and scheduled for a spontaneous breathing trial
• • Richmond Agitation Sedation Scale (RASS) between -1 and +1
• * Patient at high risk of re-intubation with at least one of the following criteria:
• • Underlying cardiac disease (left ventricular dysfunction with left ventricular ejection fraction ≤ 45%, documented ischemic heart disease, chronic atrial fibrillation, known history of cardiogenic pulmonary edema)
• • Underlying respiratory disease (COPD, Emphysema, bronchial dilatation, asthma, obesity/hypoventilation syndrome, restrictive lung disease)
• Exclusion Criteria:
• • Neuromuscular pathology (myasthenia type) preceding hospitalization
• • Pregnant or breast-feeding women
• • Patient already included in the study
• • Protected person (under guardianship or curatorship)
• • Person under court protection
• • Person not affiliated to a social security scheme