Treatment Of Meta-diaphyseal Bone Defect In Long Bone With Titanium Mesh Cage

Launched by ASSIUT UNIVERSITY · Apr 4, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment for patients with significant bone defects in long bones, such as the femur, tibia, or humerus. These defects can occur due to trauma or chronic issues like infections and can be challenging to treat with traditional methods. The study is focusing on the use of a titanium mesh cage, which provides strong support and helps the body heal by holding bone graft material in place. This method has shown promising results in previous studies, with good healing rates and improved function for patients.

To participate in the trial, you need to be between 16 and 60 years old and have a bone defect that is at least 2 cm long. Unfortunately, some individuals may not be eligible, such as those with active infections or severe health issues that would prevent surgery. If you qualify, you can expect close monitoring and support throughout the treatment process. Overall, this trial aims to find a safer and more effective way to help heal complex bone injuries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: Patients aged 16-60 years (adults of any gender)
• • Defect Location: Meta-diaphyseal defects in long bones (femur, tibia, humerus)
• • Defect Size: Critical-sized defects ≥2 cm in length
• • Case Type: Both acute (traumatic/post-traumatic) and chronic (osteomyelitis, non-union) presentations
• * Exclusion Criteria:
• • Soft Tissue Status: Inadequate soft tissue coverage requiring complex reconstruction (unreconstructable defects)
• • Infection: Active local or systemic infection (e.g., unresolved osteomyelitis, sepsis)
• • Host Status: Severe immunocompromise or systemic conditions contraindicating surgery (e.g., uncontrolled diabetes, renal failure)
• • Prior Interventions: Previous failed reconstruction attempts with persistent instability