A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

Launched by CRISPR THERAPEUTICS · Apr 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called CTX112 for adults who have certain autoimmune diseases that are difficult to manage, such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and idiopathic inflammatory myopathy (IIM). The goal is to see how safe the treatment is and whether it can help improve symptoms for those who have not responded well to other therapies. The trial is currently recruiting participants aged 18 to 70 who meet specific health criteria, including a confirmed diagnosis of one of these conditions.

Participants in this trial will receive CTX112 and will be closely monitored for their safety and any changes in their condition. To be eligible, individuals must be willing to follow the study requirements, including attending scheduled visits and using contraception if needed. There are certain health conditions and past treatments that may exclude someone from participating, so it’s important for potential participants to discuss their medical history with the research team. Overall, this trial offers a chance to explore a new treatment option for those struggling with these challenging autoimmune diseases.

Gender

ALL

Eligibility criteria

• Key Inclusion Criteria:
• • 1. Age ≥18 years and \< 70 years of age.
• • 2. Subjects must voluntarily sign a written informed consent and be willing and able to comply with all study requirements.
• • 3. Adequate hematologic, renal, liver, cardiac and pulmonary organ function.
• • 4. Subjects must agree to use acceptable methods of contraception.
• • 5. Willing and able to comply with scheduled visits, treatment plan, laboratory tests, contraceptive guidelines, and other study procedures.
• • 6. Diagnosis of systemic lupus erythematosus (SLE), systemic sclerosis (SSc) or idiopathic inflammatory myopathy (IIM).
• For systemic lupus erythematosus (SLE) subjects:
• • - Diagnosis of SLE by a board-certified rheumatologist that conforms with 2019 ACR/EULAR criteria. For lupus nephritis subjects, active, biopsy-proven proliferative lupus nephritis Class III or IV, either with or without the presence of Class V, and appropriate National Institutes of Health index activity score using the 2018 International Society of Nephrology/Renal Pathology Society criteria.
• For Systemic Sclerosis (SSc) subjects:
• • - Diagnosis of diffuse cutaneous systemic sclerosis (dcSSC) or SSc-ILD that conforms with 2013 ACR/EULAR criteria. Subjects should meet active skin or lung disease criteria.
• For Idiopathic Inflammatory Myopathy (IIM) subjects:
• • - Diagnosis with dermatomyositis (DM), polymyositis (PM) or myositis as part of rheumatologic overlap syndrome, antisynthetase (ASyS), or immune-mediated necrotizing myopathy (IMNM) that conforms with 2017 ACR/EULAR criteria for inflammatory myopathies. Subjects must meet moderate severe, skin, or lung involvement criteria.
• Key Exclusion Criteria:
• • 1. Prior anti-CD19 therapy or any gene therapy/genetically modified cell therapy.
• • 2. Prior solid organ (heart, liver, kidney, lung) transplant or hematopoietic cell transplant.
• • 3. Severe active or history of central nervous (CNS) involvement.
• • 4. History of a seizure disorder, cerebrovascular ischemia/hemorrhage, dementia, cerebellar disease or any autoimmune disease with CNS involvement other than SLE, SSc or IIM.
• • 5. Mixed connective tissue disease with no clear predominant disease.
• • 6. Presence of study disease manifestations or other conditions that are likely to pose increase safety risks and/or confound disease assessments, or pose significant risk to those receiving CAR T cell therapy.
• • 7. History of primary or secondary immunodeficiency.
• • 8. Presence or history of certain bacterial, viral or fungal infection.
• • 9. Malignancy in the last 5 years (with the exception of cancers deemed to be low likelihood for recurrence).
• • 10. Diagnosis of a genetic disorder associated with bone marrow failure or myelodysplastic syndrome.
• • 11. History or current diagnosis of catastrophic anti-phospholipid syndrome or anti phospholipid syndrome that requires ongoing anticoagulation.
• • 12. Pregnant or lactating.
• • 13. Presence or history of disease requiring treatment that is not compatible with the study protocol; presence or history of other conditions that are not compatible with the study protocol.