Clinical and Volumetric Changes Following Single Pontic Site Development Using Multilayered Platelet Rich Fibrin Versus Connective Tissue Grafting in the Maxillary Esthetic Zone

Launched by CAIRO UNIVERSITY · Apr 7, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different methods for improving the appearance and health of the gums in the mouth after losing a tooth, specifically in the area of the upper jaw where the front teeth are located. The researchers want to compare a technique using multilayered Platelet Rich Fibrin (PRF), which is a natural substance made from your own blood, to the traditional method using connective tissue grafting (SCTG), which involves taking tissue from another part of your mouth. The goal is to see which method is better at helping restore the gum area and making it look more natural after tooth loss.

To participate in this study, you need to be an adult aged 18 to 40 who has lost teeth in the upper jaw between the second premolar teeth and has some gum tissue loss in that area. You should also have healthy gums with at least 2mm of a specific type of tissue called keratinized tissue. However, if you smoke, are pregnant, have certain health conditions that might affect healing, or if you have an active infection in your gums, you won't be eligible to join. If you take part in the trial, you'll be informed about the procedures and what to expect during the study, and you'll receive care aimed at improving your gum health and appearance.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults from the age of 18 - 40 years
• • Patients with missing maxillary teeth/tooth in the area from 2nd premolar to 2nd premolar with ridge defect according to Seibert classification (Class I, II and III).
• • Intact gingival tissue with at least 2mm keratinized tissue.
• • Periodontally healthy patients.
• • Patients accepts to provide informed consent.
• Exclusion Criteria:
• • Smokers.
• • Pregnant females.
• • Handicapped and mentally challenged patients.
• • Systemic disease compromising wound healing.
• • Active soft tissue infection