9MW2821 Combined With Other Antitumor Drugs in Patients With Advanced Gynecological Tumors

Launched by MABWELL (SHANGHAI) BIOSCIENCE CO., LTD. · Apr 8, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new treatment called 9MW2821, which is being tested in combination with other cancer-fighting medications for women who have advanced gynecological tumors. The main goal is to see how safe this treatment is and how well it works. The trial is not recruiting participants yet, but when it starts, it will involve women between the ages of 18 and 75 who have been diagnosed with certain types of advanced cancers of the reproductive system.

To join the study, participants will need to meet some specific criteria, such as having measurable cancer that can be evaluated and being in good enough health to tolerate the treatment. They will also need to provide tumor tissue samples for testing. Participants can expect close monitoring throughout the trial and will be required to follow certain guidelines, such as using contraception if they are of childbearing age. Overall, this trial aims to provide insight into a potentially new treatment option for women facing challenging gynecological cancers.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Competent to comprehend, sign, and date an independent ethics committee/institutional review board/research ethics board (IEC/IRB/REB) approved informed consent form.
• • 2. Female subjects aged 18 to 75 years (including 18 and 75 years).
• • 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• • 4. Histopathological diagnosed of advanced gynecological tumors.
• • 5. Subjects must submit tumor tissues for test.
• • 6. Life expectancy of ≥ 12 weeks.
• • 7. Subjects must have measurable disease according to RECIST (version 1.1).
• • 8. Adequate organ functions.
• • 9. Sexually active fertile subjects must agree to use methods of contraception during the study and at least 180 days after termination of study therapy.
• • 10. Subjects are willing to follow study procedures.
• Exclusion Criteria:
• • 1. History of another malignancy within 3 years before the first dose of study drug.
• • 2. Patients with ongoing clinically significant toxicities related to prior treatment.
• • 3. Presence of Grade ≥ 2 peripheral neuropathy.
• • 4. Exclusion of prior diseases and prior treatments as specified in the protocol.
• • 5. Comorbidities: a. Hemoglobin A1C ≥ 8%; b. Ocular diseases or symptoms present prior to the first dose of study medication; c. Severe respiratory diseases; d. Clinically significant cardiovascular or cerebrovascular diseases within 6 months prior to the first dose of study medication; e. Active autoimmune diseases within 2 years prior to the first dose of study medication, or a history of autoimmune diseases with potential for recurrence; f. Active infections; g. Severe arterial or venous thromboembolic events.
• • 6. Clinically significant bleeding symptoms or a clear bleeding tendency within 3 months prior to the first dose of medication.
• • 7. Subjects with central nervous system (CNS) metastases and/or carcinomatous meningitis.
• • 8. Pleural, peritoneal, or pericardial effusion with clinical symptoms or requiring repeated drainage procedures.
• • 9. Prior Treatments: a. Major surgical procedures within 28 days prior to the first dose of study medication; b. Administration of other investigational drugs or experimental medical devices within 28 days prior to the first dose of study medication; c. Use of P-glycoprotein inhibitors or inducers, or potent CYP3A4 inhibitors within 14 days prior to the first dose of study medication; d. Receipt of live vaccines within 28 days prior to the first dose of study medication or planned administration of any live vaccine during the study period; e. Prior allogeneic hematopoietic stem cell transplantation or solid organ transplantation;.
• • 10. Subjects with a history of drug abuse or psychiatric disorders, or suspected allergy, intolerance, or severe infusion reactions to the investigational drug or any of its components.
• • 11. Pregnant or lactating women.
• • 12. Not suitable to receive study treatment for other conditions as per investigator.