The Study on the Efficacy of tDCS Stimulation of the Cerebellum Combined With XingNaoJing Injection in Patients With Consciousness Disorders After Cranial Injury

Launched by THE SECOND AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIVERSITY · Apr 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a treatment that combines a technique called transcranial direct current stimulation (tDCS) with a herbal injection called XingNaoJing. The goal is to see if this combination can help patients who have problems with their consciousness after a brain injury. Specifically, researchers want to find out if certain brain tests can help tell the difference between two types of consciousness disorders. They are also interested in whether this treatment can improve patients' awareness and brain function.

To be eligible for this trial, participants need to be between 18 and 80 years old and have been diagnosed with a disturbance of consciousness for at least a month after their initial head injury. They should also have shown stable consciousness for at least two weeks before joining the study. Participants will undergo brain stimulation and receive the injection, and researchers will monitor their progress. It’s important to note that the trial is not yet recruiting participants, so there will be more information to come about how to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. aged 18-80 years;
• • 2. All patients met the diagnostic criteria of DoC;
• • 3. more than 1 month after the initial head injury;
• • 4. stable consciousness for at least 2 weeks before admission (no change in CRS-R total score);
• • 5. no skull defect or large area of skull repair;
• • 6. The legal representative authorized by the patient approved the experimental protocol and signed the informed consent form.
• Exclusion Criteria:
• • 1. supratentorial abnormalities on computed tomography (CT) or magnetic resonance imaging (MRI) involving more than one third of the middle cerebral artery territory;
• • 2. a life expectancy of less than 3 months or a follow-up of less than 3 months;
• • 3. retention of intracranial metal objects, cranial debridement, or presence of cranial defects and any clinically significant or unstable medical diseases;
• • 4. EEG recording with significant muscle artifacts and inhibitory bursts;
• • 5. nonconvulsive status epilepticus; Periodic or burst rhythms evoked by stimulation;
• • 6. disturbance of consciousness due to surgical injury or tumor.