A Prediction Model of Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery

Launched by CHINA-JAPAN FRIENDSHIP HOSPITAL · Apr 8, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on developing a tool to predict which patients may need to stay on a breathing machine (mechanical ventilation) for a longer time after surgery for acute type A aortic dissection, a serious heart condition. The study aims to understand how often this happens, how long patients might need to stay in the intensive care unit (ICU), and the overall risks involved after surgery.

To participate, individuals must be at least 18 years old and have been diagnosed with acute type A aortic dissection through specific imaging tests. They should also have undergone surgery that required the use of a heart-lung machine and have been placed on a breathing machine in the ICU. However, those with certain severe health issues or who unfortunately do not survive the first few days after surgery will not be included in this study. While the trial is not yet recruiting participants, it aims to gather important information that could help improve outcomes for future patients undergoing similar surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years;
• • Diagnosis of acute type A aortic dissection (ATAAD) confirmed by computed tomography angiography and echocardiography;
• • Patients who underwent aortic surgery requiring cardiopulmonary bypass (CPB), were admitted to the surgical intensive care unit (SICU), and received mechanical ventilation.
• Exclusion Criteria:
• • Reintubation;
• • Intraoperative death or failure to survive beyond 72 hours postoperatively;
• • Pregnancy;
• • Severe comorbidities (e.g., lung cancer);
• • Missing critical outcome data (e.g., short-term mortality, mechanical ventilation duration, reintubation).