Comparison Between Intravenous Hydrocortisone and Ondansetron in Prevention of Post Spinal Anesthesia Hypotension

Launched by NADA KAMEL ELGAMAL · Apr 9, 2025

Keywords

ClinConnect Summary

According to the medication investigated in this study, patients will be divided into three equal groups (40 each). Patients will receive one of the following 15 minutes before spinal anesthesia:

1. Hydrocortisone 100 mg (H group)
2. Ondansetron 8 mg (O group)
3. An identical volume of sterile distilled water (Control group) (C group).

Spinal anesthesia will be performed under complete aseptic conditions with the patient seated, a 25-gauge Quincke spinal needle is used to administer 3.5 ml of a 0.5% hyperbaric bupivacaine together with 25 micrograms of fentanyl at the L3-L4 or L4-L5 level...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. ASA I and II (physical status according to American Society of Anesthesiologists).
• • 2. Patients aged 21 years or more.
• • 3. Either sex.
• • 4. Abdominal and lower limb operations.
• Exclusion Criteria:
• • 1. Patient refusal.
• • 2. hemodynamic instability
• • 3. Hematological diseases, bleeding or coagulation abnormality.
• • 4. Local skin infection and sepsis at site of spinal anesthesia
• • 5. neuromuscular diseases (as myopathies, myasthenia gravies...)
• • 6. Preexisting neurological deficit or psychiatric diseases.
• • 7. Known intolerance to the study drugs.
• • 8. patients already receiving any of the study drugs.
• • 9. diabetic patient.