MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes

Launched by MEDICAL COLLEGE OF WISCONSIN · Apr 9, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to explore how two potential treatments might improve blood vessel health in stroke survivors. Researchers want to see if a single session of ischemic conditioning (a method that temporarily reduces blood flow to improve circulation) or taking an antioxidant supplement called MitoQ can help these individuals regain better vascular function. This is important because poor blood vessel health can increase the risk of having another stroke or other heart-related issues, and it can make physical activity more challenging.

To be eligible for this study, participants need to be between 18 and 85 years old and have experienced a stroke at least six months prior, leading to some weakness on one side of their body. They should be able to understand simple instructions and communicate in English. Participants will not be able to join if they have certain health conditions, like severe heart problems or history of blood clots, which could affect their safety in the trial. The study is still in the early stages and has not started recruiting participants yet, but individuals who qualify will have the opportunity to contribute to research that could benefit future stroke survivors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 - 85 years of age
• • Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis
• • Able to give informed consent and follow 2-step command.
• • English Speaking
• Exclusion Criteria:
• • Unable to stand from chair without physical assistance from another person (able to use assistive device).
• • History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg).
• • Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization)
• • History of head trauma or concussion within the past 6 months
• • Comorbid neurological disorder
• • Peripheral vascular disease
• • Myocardial infarction or arrhythmia in the previous year
• • Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg
• • Pregnant or breastfeeding.
• • Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator