The NACHO Trial (Nut Allergy Children OIT)

Launched by HUS SKIN AND ALLERGY HOSPITAL · Apr 9, 2025

Keywords

ClinConnect Summary

The NACHO Trial is studying a new treatment called oral immunotherapy (OIT) for children with cashew nut allergies. This study aims to see if gradually introducing cashew nuts into a child's diet can help them become less sensitive to them, potentially allowing them to eat cashew nuts safely in the future. The trial is open to children aged 6 months to 17 years who have been diagnosed with a cashew nut allergy, confirmed by specific tests.

If your child participates in the trial, they will follow a carefully monitored plan to consume small amounts of cashew nuts over time. Researchers will closely watch for any side effects and assess how this treatment affects your child's quality of life. The trial is currently recruiting participants, and it’s important to note that some health conditions may prevent a child from joining, such as uncontrolled asthma or certain severe illnesses. This study could offer hope for children with nut allergies and their families by exploring a way to increase tolerance to cashew nuts.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age 6 months - 17 years
• • 2. Sensitization to cashew nut (allergen-specific IgE or positive skin PRICK test)
• • 3. Positive oral food challenge for cashew nut
• Exclusion Criteria:
• • 1. Poor adherence
• • 2. Uncontrolled or severe asthma
• • 3. Uncontrolled active or severe or atopic dermatitis
• • 4. Chronic urticaria
• • 5. Eosinophilic esophagitis or other gastrointestinal eosinophilic disorders
• • 6. Active malignant neoplasia
• • 7. Active systemic, autoimmune disease
• • 8. Diabetes treated with insulin
• • 9. Severe systemic illness or severe medical conditions such as cardiovascular or lung diseases
• • 10. Medication with beta blockers
• • 11. Medication with ACE-inhibitors
• • 12. Mastocytosis
• • 13. Pregnancy or breastfeeding
• • 14. Language barriers (not fluent Finnish or Swedish)