Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet Rich Plasma to Treat Idiopathic Glossopharyngeal Neuralgia (GPN)

Launched by BEIJING TIANTAN HOSPITAL · Apr 15, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new treatment for idiopathic glossopharyngeal neuralgia (GPN), a condition that causes severe pain in the throat and ear area. The study will explore whether using pulsed radiofrequency (a type of nerve treatment) combined with platelet-rich plasma (a substance made from your own blood that can help healing) is effective and safe for relieving pain in patients who haven't found relief with medications.

To be eligible for the trial, participants need to be over 18 years old and have been diagnosed with GPN. They should also have not found relief from pain medications or have experienced side effects that they couldn’t tolerate. However, individuals with certain health issues, such as infections, serious blood or organ problems, or those who are pregnant or breastfeeding, cannot participate. If you join the trial, you can expect to receive the treatment and be followed up for at least a month to see how well it works for you. This trial is currently recruiting participants, so if you meet the criteria and are interested, you could play a role in helping improve treatment for GPN.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. age \>18 years;
• • 2. diagnosed with idiopathic GPN according to the third International Classification of Headache Disorders (ICHD) classification;
• • 3. patients who failed pharmacotherapy or intolerable side effects of medication;
• • 4. undergoing PRF for GPN;
• • 5. at least 1 month of follow-up recordings.
• Exclusion Criteria:
• • 1. Patients with bilateral GPN;
• • 2. Abnormalities in blood measurements, liver and kidney function, blood glucose, coagulation, electrocardiography or chest radiography;
• • 3. Infection at the puncture site;
• • 4. Previous mental illness;
• • 5. Previous history of narcotic drug abuse;
• • 6. Prior anticoagulant or antiplatelet therapy;
• • 7. An implantable pulse generator;
• • 8. Current pregnancy or breast feeding.
• • 9. Patients with incomplete medical records (lack of baseline data or postoperative follow-up data).