The Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) Targeting the Right Globus Pallidus Internus (GPi) for Motor Symptoms in Patients With PD

Launched by YANGHUA TIAN · Apr 9, 2025

Keywords

ClinConnect Summary

Each of patients received either 30-minute or sham tTIS of the right GPi. Before and immediately after the stimulation, participants completed the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) in the "medication-on" state to assess the motor symptoms. MDS-UPDRS, HAMA and HAMD were assessed on intervention Day 1, Day 10 and 1-month follow-up and clinical efficacy was evaluated by comparing the scale scores before and after the intervention.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Meeting the diagnostic criteria for Parkinson's disease in China (2016 version), diagnosed as PD by two neurologists;
• • 2. Hoehn-Yahr stage 1.5-4;
• • 3. Age \> 50 years old;
• • 4. No signs of moderate to severe depression: Beck Depression Inventory-II (BDI-II) score \< 20;
• • 5. No signs of dementia: Mini-Mental State Examination (MMSE) score \> 21;
• • 6. No change in medication regimen in the four weeks prior to enrollment;
• • 7. Right-handed.
• Exclusion Criteria:
• • 1. History of other neuropsychiatric disorders;
• • 2. History of alcohol or drug abuse;
• • 3. Previous history of TMS or traditional TES treatment;
• • 4. Presence of non-MRI compatible metal implants in the body, such as deep brain stimulation devices, pacemakers or stents.