Reprogramming Energy Homeostasis in Overweight Individuals Via Exercise, Cognitive, and Social Training

Launched by BAMBINO GESÙ HOSPITAL AND RESEARCH INSTITUTE · Apr 9, 2025

Keywords

ClinConnect Summary

The RESILIENT project is a clinical trial aimed at understanding how to improve the body's response to a hormone called leptin in individuals who are overweight or obese, including both children and adults. Leptin helps control hunger and energy balance, but some people can become resistant to its effects. This study will explore whether combining Cognitive Training (which focuses on thinking skills) and Social Training (which emphasizes social interactions) can enhance leptin sensitivity more effectively than a standard health behavior program that includes diet and exercise. Participants will be involved in an 8-week program followed by a 12-week period without interventions.

To join the study, individuals must be aged between 21 and 40, have a condition of overweight or obesity, and have a minimum IQ of 85. Those with certain types of genetic obesity, mobility issues, systemic diseases, or who are currently on medication for chronic conditions will not be eligible. Throughout the trial, participants will undergo various assessments to measure how effective these interventions are, which may help lead to better long-term treatments for obesity and its related challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • a condition of overweight or obesity
• • Intelligence Quotient (IQ) ≥ 85
• Exclusion Criteria:
• • genetic or syndromic obesity;
• • reduced mobility;
• • systemic diseases;
• • ongoing pharmacological treatment for chronic conditions.