Effects of Uremia on Brachial Plexus Electrophysiology and Brachial Plexus Block

Launched by NANJING FIRST HOSPITAL, NANJING MEDICAL UNIVERSITY · Apr 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a serious condition called uremia, which occurs in patients with late-stage kidney failure, affects the nerves in the arm. Uremia can lead to various complications, including problems with the nerves, which may impact how well nerve blocks work during surgeries on the forearm or hand. The trial will specifically look at the safety and effectiveness of a new technique called ultrasound-guided axillary brachial plexus block, which helps doctors numb the arm for surgery.

To participate in the study, you need to be at least 18 years old and planning to have surgery on your forearm or hand. There are two groups in the study: one group will include patients with uremia, and the other will include patients without this condition but who might have diabetes. Participants will need to provide informed consent, meaning they agree to take part in the study and understand what it involves. The trial is not yet recruiting participants, but it aims to help improve care for patients with kidney failure who need surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Uremia group \[group U\]
• • 1. Patients aged 18 years and older
• • 2. ASA classification I-IV
• • 3. BMI 18.5-29.9
• • 4. Patients with uremia planning to undergo forearm or hand surgery
• • 5. Diagnostic criteria: Patients must meet the internationally recognized diagnostic criteria for uremia and require hemodialysis
• • 6. Informed consent: Patients or their legal representatives must sign an informed consent form, agreeing to participate in this study and undergo related examinations and treatments
• • Non-uremia group \[Group N\]
• • 1. Patients aged 18 years and older
• • 2. ASA classification I-IV
• • 3. BMI 18.5-29.9
• • 4. Patients planning to undergo forearm or hand surgery
• • 5. In addition to possibly having diabetes, patients should not have any other diseases that could cause peripheral neuropathy
• • 6. The patient or their legal representative must sign an informed consent form, agreeing to participate in this study and receive the relevant examinations and treatments
• Exclusion Criteria:
• • Individuals allergic to study medications (such as ropivacaine)
• • Those with contraindications to local anesthesia or nerve blockades, such as coagulation disorders, infections, etc.
• • Those with severe cardiovascular or respiratory diseases
• • Those unable to comply with study requirements, such as cognitive impairment, mental disorders, etc.
• • Pregnant women