The BRAINMAP-DBS Study: BRain Network AnalysIs usiNg 7-Tesla MRI and MAgnetoencephalograPhy for Deep Brain Stimulation

Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · Apr 10, 2025

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ClinConnect Summary

The BRAINMAP-DBS study is exploring how advanced brain imaging techniques can improve the outcomes of deep brain stimulation (DBS) for patients with Parkinson’s disease and essential tremor. DBS is a treatment that helps reduce symptoms, but not all patients see significant improvement. This study aims to use a special type of MRI (7-Tesla MRI) and magnetoencephalography (MEG) to get a clearer picture of the brain’s motor networks. By doing this, researchers hope to better guide where electrodes are placed during DBS and how the stimulation is adjusted, potentially leading to better symptom control and improved quality of life for patients.

To be eligible for the study, participants must be over 18 years old, have been diagnosed with Parkinson’s disease or essential tremor, and have received DBS for at least six months. They must also have undergone a preoperative 7-Tesla MRI scan. If someone joins the study, they can expect to have their motor skills and quality of life assessed before and after adjustments to their DBS settings based on the advanced imaging results. This study poses negligible risk and focuses on non-invasive techniques that are part of standard care, aiming to provide better treatment outcomes for those living with these conditions.

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Eligibility criteria

• Inclusion Criteria:
• In order to be eligible to participate in this study, a subject must meet all of the following criteria:
• • Age \> 18 years;
• • Idiopathic PD/ET with at least six months of DBS
• • Underwent a preoperative 7-Tesla MRI scan
• Exclusion Criteria:
• A potential subject who meets any of the following criteria will be excluded from participation in this study:
• • Legally incompetent adults;
• • No written informed consent.
• • A spinal stimulation or deep brain stimulation system is not compatible with 7-Tesla MRI
• • There a no implants inadmissible in the MEG, although patients will be questioned for possible (non-removable) implants such as pacemakerand/or dental as they may interfere with the magnetic signals