The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus

Launched by CHULALONGKORN UNIVERSITY · Apr 10, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment for a condition called oral lichen planus (OLP), which causes painful sores in the mouth. Specifically, the study is comparing the effects of curcumin, a natural compound found in turmeric, delivered in a special gel, to a standard corticosteroid paste called fluocinolone acetonide. The goal is to see if the curcumin gel is as effective and better tolerated than the standard treatment.

To participate in this trial, you need to be at least 18 years old and have been diagnosed with atrophic or erosive oral lichen planus that causes discomfort. You should also be able to provide consent and follow treatment instructions. However, certain conditions, like pregnancy, uncontrolled diabetes, or a history of severe mouth dryness, might prevent you from joining. If you decide to take part, you’ll apply the treatment as directed and attend follow-up visits. This trial is not yet recruiting participants, so more information will be available soon.

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Eligibility criteria

• Inclusion Criteria:
• • Age 18 years or older
• • Ability to provide written informed consent
• • Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP)
• • Presence of symptoms (NRS pain score \> 0 at baseline)
• • Ability to communicate and follow instructions
• • Willingness to apply oral paste treatment and comply with study protocol
• Exclusion Criteria:
• • Pregnancy or lactation
• • Current orthodontic treatment
• • Uncontrolled diabetes mellitus (HbA1c \> 7% or FPG \> 130 mg/dL)
• • Use of anticoagulants or antiplatelet agents
• • Severe dry mouth (Challacombe score \> 7)
• • History of gastric ulcers, duodenal ulcers, or gallstones
• • Presence of any active malignancy or infection
• • Use of topical/systemic treatment for OLP in the past 2 weeks
• • Current use of immunosuppressants
• • Known allergy to corticosteroids or herbal agents such as turmeric
• • Diagnosis of oral lichenoid contact lesion or graft-versus-host disease (GVHD)
• • History of allogeneic bone marrow transplantation
• • Current smokers