Impact of Diabetic Polyneuropathy on Carpal Tunnel Syndrome: Shear Wave Elastography, Ultrasound, and Hand Function

Launched by ANKARA ETLIK CITY HOSPITAL · Apr 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how diabetic polyneuropathy (a nerve condition related to diabetes) affects carpal tunnel syndrome (CTS), a condition that can cause pain, numbness, and weakness in the hands. Researchers will use special imaging techniques to look at changes in the median nerve, which runs through the wrist and can be compressed in CTS. The goal is to understand how having diabetes, diabetic polyneuropathy, and carpal tunnel syndrome together can influence symptoms and hand function.

To participate, individuals must be between 18 and 78 years old and have symptoms of carpal tunnel syndrome, such as pain or tingling in the hands. They should also be able to understand the study and give their consent to join. The trial is not yet recruiting participants, but it’s important to note that those with certain medical histories, like previous surgeries on the wrist or severe nerve damage, may not be eligible. Participants can expect to undergo tests involving imaging and assessments of their hand function, helping researchers learn more about the relationship between these conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Patient Group:
• • Presence of carpal tunnel syndrome (CTS) symptoms, including pain, numbness, tingling, burning, and weakness, which worsen during sleep, prolonged hand positions, or repetitive wrist movements, and improve with hand shaking or changing position.
• • Cognitively able to understand and participate in the study.
• • Aged between 18 and 78 years.
• • Has given written informed consent to participate.
• Control Group:
• • Asymptomatic individuals, with or without diabetes.
• • Cognitively able to understand and participate in the study.
• • Aged between 18 and 78 years.
• • Has given written informed consent to participate.
• Exclusion Criteria:
• • History of previous carpal tunnel surgery or injection.
• • History of previous upper extremity trauma.
• • Presence of mass lesions or any condition that compresses the median nerve, observed during ultrasonographic examination.
• • Presence of a persistent median artery.
• • Presence of a bifid or trifid median nerve.
• • Presence of anastomoses, such as Martin-Gruber.
• • History of long-term excessive alcohol consumption.
• • Chronic renal failure.
• • Presence of neuropathy due to a neurological condition.
• • Thyroid disorders.
• • History of malignancy.
• • History of neurotoxic drug use.
• • Peripheral arterial occlusive disease.
• • Severe diabetic polyneuropathy (DPN) diagnosis.
• • Pregnancy.
• • Cervical radiculopathy or brachial plexopathy.
• • Osteoarthritis of the hand.
• • Rheumatologic disease.
• • Systemic autoimmune disease.
• • History of cerebrovascular disease.
• • Dupuytren's contracture.
• • Sclerodactyly.
• • Cognitive limitations that would prevent understanding the study protocol.