Losartan to Improve Outcomes After Multi-ligament Knee Injury

Launched by BRIGHAM AND WOMEN'S HOSPITAL · Apr 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a medication called Losartan can help people recover better after a serious knee injury known as a multi-ligament knee injury (MLKI). These injuries can happen during activities like sports or military training and often require surgery to repair the damaged ligaments. Unfortunately, many patients face complications after surgery, such as limited movement in their knee, which can affect their ability to return to work or sports. The trial aims to see if taking Losartan for 30 days after surgery can improve knee movement, strength, and reduce inflammation, helping participants get back to their daily activities more effectively.

To be eligible for this trial, participants must have a complete tear of two or more knee ligaments and have had at least one of these ligaments surgically repaired. They should also be willing to follow the study's guidelines. However, individuals who are non-English speakers, pregnant, or have certain health conditions that could increase risks with Losartan won’t be able to participate. This study is still in its planning stages and has not started recruiting participants yet, but it offers a potential new approach to improving recovery after a challenging knee injury.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Multi-ligament knee injury defined as a complete grade III injury of 2 or more ligaments
• • At least one ligament surgically reconstructed or repaired
• • Willingness to comply with the study protocol and assessments
• Exclusion Criteria:
• • Non-English speaking
• • Allergic to any active or inactive ingredient of losartan
• • Pregnant, planning to become pregnant, or sexually active females choosing not to use effective means of contraception during the 30-day course of losartan
• • Those at increased risk of losartan related side effects including those with severe renal insufficiency, hepatic disease, hypotension, and/or hyperkalemia
• • Have a history of prior knee ligament surgery of the involved knee
• • Undergoing staged surgical procedures in the treatment of MLKI
• • Have a traumatic brain injury that limits their ability to participate in their postoperative care or any condition that would preclude the ability to comply with postoperative rehabilitation
• • Have a concomitant injury or underwent a surgical procedure that will preclude the ability to perform range of motion exercises (i.e. surgery for extensor mechanism rupture or avulsion, vascular graft surgery)